Protein Modification Reagents
Sigma Aldrich Fine Chemicals Biosciences GUANIDINE HYDROCHLORIDE 5KG
NC3886657 GUANIDINE HYDROCHLORIDE 5KG
Sigma Aldrich Fine Chemicals Biosciences GUANIDINE HYDROCHLORIDE 2KG
NC3886659 GUANIDINE HYDROCHLORIDE 2KG
AdipoGen Guanidine hydrochloride
Chemical. CAS 50-01-1. Formula CH5N3 . HCl. MW 59.07 . 36.46. Guanidine hydrochloride is a powerful, chaotropic agent which is widely used for purification of proteins and nucleic acids. It is useful for denaturation and refolding of proteins as well as in the recovery of periplasmic proteins. At higher concentrations, this strong denaturant has been reported to solubilize denatured insoluble proteins such as inclusion bodies and to increase the solubility of hydrophobic molecules. When utilized at lower concentrations, it is useful in prompting the refolding of denatured proteins. Guanidine hydrochloride is also been reported to allow return of enzymatic activity in protocols using it as a first step. Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Cayman Chemical PROTAC CRBN Degrader-1 5mg
A PROTAC that drives CRBN degradation (DC50 = 200 nM in HeLa cells)
Medchemexpress LLC Cyclin K degrader 1 | 3055008-98-2 | 99.9% | 466.32 | 5 MG
Cyclin K degrader 1 (compound 40) is an AT7519 based Cyclin K degrader with a DC50 of 21 nM. It demonstrates an affinity for cyclin K that is approximately 500-fold higher than its affinity for CDK12.
- Degrades cyclin K in the presence of DDB-1.
- Achieves 99 ± 1 % cyclin K degradation.
- Has a DC50 of 21 nM.
- Exhibits Dmax >95%.
- Features a CDK12 Kd of 1000 nM.
Research Products International Corp Guanidine Hydrochloride, 500 Grams
Protein denaturant used for purifying proteins and nucleic acids.
Medchemexpress LLC HDAC6 degrader-1 | 2439058-23-6 | 95.7% | 795.84 | C40H45N9O9 | 5 MG
HDAC6 degrader-1 is a proteolysis-targeting chimera (PROTAC) designed to selectively induce degradation of histone deacetylase 6 (HDAC6) in cell-based studies. It links an HDAC6-binding ligand to an E3 ligase recruiter to promote ubiquitination and proteasomal clearance of the target protein, and has been reported to show potent cellular activity.
- Selective degradation of HDAC6 in cells
- Potent cellular activity: DC50 3.8 nM in MM.1S cells
- Research-grade solid with high purity (95.7%)
- Molecular weight 795.84 for assay planning
- Available in small research pack sizes suitable for in vitro studies
- Store sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month)
Medchemexpress LLC BTK degrader-1 | 2377645-56-0 | 99.4% | 925.03 | 5 MG
BTK degrader-1 is a Bruton's tyrosine kinase (BTK) bifunctional degrader that can be conjugated with CD79b. It has an anti-tumor effect.
- For research use only
- To be handled by experienced personnel in appropriately equipped and authorized facilities
- Not fully validated for medical applications
Medchemexpress LLC Methyl-PEG4-NHS ester | 622405-78-1 | MFCD11041112 | 95.0% | 333.33 | C14H23NO8 | 10G
Methyl-PEG4-NHS ester is a methyl-capped polyethylene glycol linker terminating in an N-hydroxysuccinimide (NHS) ester. It is used for amine-targeted bioconjugation and as a flexible PEG spacer in bifunctional molecules, enabling efficient formation of stable amide bonds and improved solubility.
- Provides an NHS ester for rapid conjugation to primary amines.
- Methyl-capped PEG4 spacer increases solubility and linker flexibility.
- Suitable for PROTAC synthesis and general bioconjugation applications.
- Molecular weight 333.33 and molecular formula C14H23NO8.
- CAS number 622405-78-1 and MFCD11041112 for reference.
- Typical purity around 95.0% and available in multiple pack sizes.
Medchemexpress LLC DSPE-PEG5000 maleimide ammonium salt | 474922-22-0 | 98.4% | (C2H4O)nC51H92N1O13P.H3N | 10MG
DSPE-PEG5000-Mal is a lipid-polyethylene glycol conjugate bearing a terminal maleimide group for selective thiol coupling. It integrates into lipid bilayers to functionalize liposomes and lipid nanoparticles, while the PEG5000 chain provides steric stabilization and extended circulation in biological media.
- Maleimide-functional group enables selective thiol conjugation.
- PEG5000 chain provides steric stabilization and prolongs circulation time.
- Phospholipid anchor integrates into lipid bilayers and nanocarriers.
- High reported purity supports reproducible formulation performance.
- White to off-white solid suitable for analytical handling and storage.
Medchemexpress LLC DSPE-PEG carboxylic acid (sodium) | 1403744-37-5 | 98.0% | (C2H4O)nC45H86NO12P.Na | 25 MG
DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid that can be used in the preparation of drug delivery nanoparticles. It is capable of extending the blood circulation time and stability of liposomes, while also improving the targeting ability and cellular uptake efficiency of nanoparticles.
- Used in the preparation of drug delivery nanoparticles
- Prolongs the blood circulation time and stability of liposomes
- Enhances the targeting ability of nanoparticles
- Improves cellular uptake efficiency of nanoparticles
![eMolecules 2354291-37-3 | Gly-PEG3-endo-BCN | Broadpharm453.580 | C23H39N3O6 | 0.000 | NCC(=O)NCCCOCCOCCOCCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 550804569](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183536.JPG-250.jpg)
eMolecules 2354291-37-3 | Gly-PEG3-endo-BCN | Broadpharm453.580 | C23H39N3O6 | 0.000 | NCC(=O)NCCCOCCOCCOCCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 550804569
Gly-PEG3-endo-BCN | Broadpharm | 2354291-37-3453.580 | C23H39N3O6 | 0.000 | NCC(=O)NCCCOCCOCCOCCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 550804569